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Elfahra Casanza Amalda Farah Alhamidah Yudit Oktanella Muhammad Khuzain


Subclinical mastitis is the occurrence of inflammation in the parenchymal tissue of mammary
glands due to bacterial contamination that does not show clinical symptoms lead to impacted on
economic losses. The highest incidence of subclinical mastitis is the presence of Staphylococcus
aureus bacteria contamination. Subclinical mastitis in Indonesia is reported to reduce milk production
by up to 53.5%. Pathogenesis of Staphylococcus aureus occurs in the presence of biofilm formation as
bacterial immune system to protecting itself from disinfectants and antibiotics. In the last few decades,
the development of plasma technology has been widely used in the medical field as cancer therapy,
reducing pain, accelerating wound healing and tissue sterilization. There is no study that using the
concept of utilizing Non Termal Plasma in the field of veterinary science, especially in mastitis
therapy. Non Termal Plasma is able to decontaminate Staphylococcus aureus through inhibition and
destruction of biofilms. The mechanism of action of Non Termal Plasma in repairing mammary gland
tissue is through the destruction of DNA in the Reactive Oxygen Species (ROS) process by increasing
the growth factor TGF-1 which accelerates the process normal cell regeneration. The objective of
this study is to reviewing the efficacy of plasma non termal as subclinical mastitis theraphy. This study
was conducted through a narrative review approach by collecting international and national
literature with interval time of publication within 2010 – 2020.

Subclinical Mastitis, Non Thermal Plasma, Staphylococcus aureus
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