EFEKTIVITAS INFUSA LEMPUYANG GAJAH (Zingiber zerumbet) SEBAGAI ANTIDIARE PADA MENCIT (Mus musculus)
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Published
Nov 20, 2024
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Mustika A. EFEKTIVITAS INFUSA LEMPUYANG GAJAH (Zingiber zerumbet) SEBAGAI ANTIDIARE PADA MENCIT (Mus musculus). VITEK : Bidang Kedokteran Hewan [Internet]. 20Nov.2024 [cited 21Dec.2024];14(2):256-63. Available from: https://vitek-fkh.uwks.ac.id/index.php/jv/article/view/293
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Abstract
Lempuyang gajah (Zingiber zerumbet) rhizomes have long been consumed as food and treatment of diseases in humans. Lempuyang gajah rhizomes have potential as antidiarrheal that is cheap and easy to find, but there has been no research related to the benefits of lempuyang gajah rhizomes as antidiarrheal. The purpose of this study is to determine the effectivity of lempuyang gajah infusion as an antidiarrheal and the concentration that has the most effective antidiarrheal effect with intestinal protection method. This research also determine the content of secondary metabolites in lempuyang gajah through phytochemical tests. This study used 30 mices divided into five groups consisting of negative control group (Tween 80 [1%]), a positive control group (loperamid HCl suspension), and three groups of treatment with a lempuyang gajah infusion concentration of 25%, 50%, and 100% given orally. The parameters observed were the frequency of defecation, the consistency of faeces, and the duration of diarrhea. The conclusion of this research shows that lempuyang gajah infusion has antidiarrheal effect, lempuyang gajah infusion at a concentration of 50% showed the most effective antidiarrheal effect. Phytochemical test results show lempuyang gajah contains alkaloids and saponins
Keywords:
antidiarrhea, infusion, intestinal protection, lempuyang gajah, phytochemistry test
References
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Nasir, M.A. 2019. Praktek Terapi Pengobatan Tradisional Melayu: Sebuah Sketsa Awal. Temali: Jurnal Pembangunan Sosial. 2(1), 99–126.
Raharjo, H. 2022. Suplemen dan obat herbal: Sejarah serta gambaran pemanfaatannya dalam tindakan preventif dan kuratif pada pandemi covid-19 di Indonesia. Media Bina Ilmiah. 17(12), 7897–7916.
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Rizal, M., Yusransyah, Y., Stiani, S.N. 2017. Uji aktivitas antidiare ekstrak etanol 70% kulit buah jengkol (Archidendron paucifloum (benth.) I.C.Nielsen) terhadap mencit jantan yang diinduksi oleum ricini. Jurnal Ilmiah Manuntung. 2(2), 131.
Soetan, K.O., Oyekunle, M.A., Aiyelaagbe, O.O., Fafunso, M.A. 2006. Evaluation of the antimicrobial activity of saponins extract of sorghum bicolor L. Moench. African Journal of Biotechnology. 5(23), 2405–2407.
Sukmawati, I.K., Sukandar, E.Y., Kurniati, N.F. 2017. Aktivitas antidiare ekstrak etanol daun suji (Dracaena angustifolia Roxb). Pharmacy: Jurnal Farmasi Indonesia. 14(2), 173−187.
Suproborini, A., Laksana, M.S.D., Kartini, P.R., Putri, D.L.P. 2022. Efek antidiare ekstrak etanol daun keji beling (Strobilanthes crispus) terhadap mencit (Mus musculus) Jantan yang diinduksi castor oil. EnviroScienteae. 18(1), 210–215.
Syafitri, N.E., Bintang, M., Falah, S. 2014. Kandungan fitokimia, total fenol, dan total flavonoid ekstrak buah haendong (Melastoma affine D. Don). Current Biochemistry.1(3), 105–115.
To’bungan, N. 2020. Pemanfaatan dan skrining fitokimia infusa daun rumput knop (Hyptis capitata Jacq.). Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati. 5 (3), 149–15.
Yob, N.J., Joffry, S.M., Affandi, M.M.R., The, L.K., Salleh, M.Z., Zakaria, Z.A. 2011. Zingiber zerumbet smith: A review of its ethnomedicinal, chemical, and pharmacological uses. Evid Based Complement Alternat Med.
Yulianti, W., Ayuningtyas, G., Martini, R., Resmeiliana, I. 2020. Pengaruh metode ekstraksi dan polaritas pelarut terhadap kadar fenolik total daun kersen (Muntingia calabura L). Jurnal Sains Terapan. 10(2), 41–49.
Anggia, M., Mutiar, S., Arziah, D. 2018. Teknologi ekstraksi bunga kenanga (Cananga odorata L.) dan sereh wangi (Cymbopogon nardus L.) sebagai aroma terapi sabun cair. Jurnal Daur Lingkungan. 1(1), 5–9.
Boysen, R.I., Hearn, M.T.W. 2010. High Performance Liquid Chromatographic Separation Methods. Comprehensive Natural Products. 2. 5– 49.
Crozier, A., Clifford, M.N., Ashihara, H. 2006. Plant Secondary Metabolites: Occurrence, Structure, and Role in the Human Diet. Lowa(US): Blackwell Publishing Ltd.
Cseke, L.J., Kirakosyan, A, Kaufman, P.B., Warber, S.L., Duke, J.A., Brielmann, H.L. 2006. Natural Products from Plants Second Edition. New York (US): Taylor & Francis Group.
Erwin, I., Kusuma, D.I. 2012. Inhibitor asetilkolinesterase untuk menghilangkan efek relaksan otot non-depolarisasi. CDK-193. 39(5). 333–339.
Fahira, N.N., Sihaloho, E.D., Siregar, A.Y.M. 2021. Pengaruh konsumsi air dan keberadaan fasilitas sanitasi terhadap angka diare pada anak-anak di Indonesia. Jurnal Epidemiologi Kesehatan Komunitas. 6(2). 286–292.
Finanda, V., Qowiyyah, A., Sukandar, E.Y. 2022. Review : herbal untuk penanganan diare. Journal of Current Pharmaceutical Science. 6(1), 550–561.
Harborne, J.B. 1973. Phytochemical Methods - A Guide To Modern Techniques Of Plant Analysis. Newyork (NY) : Chapman and Hall.
Hariana, A. 2005. Tumbuhan Obat dan Khasiatnya. Jakarta (ID): Penebar Swadaya.
Indijah, S.W., Fajri, P. 2016. Modul Bahan Ajar Cetak Farmasi : Farmakologi. Jakarta: Pusdik SDM Kesehatan.
Kambu, Y.K., Azinar, M. 2021. Perilaku pencegahan diare pada balita. Indonesian Journal of Public Health and Nutrition. 1(3), 776–782.
Karlina, C.Y., Ibrahim, M., Trimulyono, G. 2013. Aktivitas antibakteri ekstrak herba krokot (Portulaca oleacea L.) terhadap Staphylococcus aureus dan Escherichia coli. LenteraBio. 2(1), 87–93.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. 2020. Profil Kesehatan Indonesia Tahun 2019. Jakarta (ID): Kementerian Kesehatan Republik Indonesia.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. 2023. Rencana Aksi Nasional Penanggulangan Pneumonia dan Diare 2023-2030. Jakarta (ID): Kementerian Kesehatan Republik Indonesia.
Khafidoh, Z., Dewi, S.S., Iswara, A. 2015. Efektivitas infusa kulit jeruk purut (Citrus hystrix DC) terhadap pertumbuhan Candida albicans penyebab sariawan secara in vitro. 2nd Univ Res Coloquium. 7(2), 31–37.
Kozvola, A.A., Lotfi, M., Okkema, P.G. 2019. Cross talk with the GAR-3 Receptor contibutes to feeding defects in Caenorhabditis elegas eat-2 mutants. Genetics. 212(1), 231– 243.
Kumar, N.R., Vijayasankar, G.R., Prema, R., Jeevanandham, S., Lakshmana, M.G., Sekar, M. 2011. Prelude studies of anti-diarrhoeal activity of ethyl acetate extract of aerial part of Indigofera purpurea on isolated rabbit ileum. Asian Journal of Pharmaceutical and Clinical Research. 4(2), 85–87.
Labu, Z.K., Laboni, F.R., Mamun, M.M.A.A., Howlader, M.S.I. 2015. Antidiarrhoeal activity and total tannin content of ethanolic leaf extract of Codiaeum variegatum. Dhaka Univ J Pharm Sci. 14(1), 87–90.
Marliana, E. 2005. Aktivitas antioksidan ekstrak etanol daun andong (Cordyline fructiosa [L] A. Cheval). Jurnal Mulawarman Scientifie. 11(1), 1412–1498.
Marwati. Amidi. 2018. Pengaruh budaya, persepsi, dan kepercayaan terhadap keputusan pembelian obat herbal. Jurnal Ilmu Manajemen. 7(2), 168– 180.
Misra, A., Srivastava, S., Srivastava, M. 2014. Evaluation of anti diarrheal potential of Moringa oleifera (Lam.) leaves. Journal of Pharmacognosy and Phytochemistry. 2(5), 43–46.
Nasir, M.A. 2019. Praktek Terapi Pengobatan Tradisional Melayu: Sebuah Sketsa Awal. Temali: Jurnal Pembangunan Sosial. 2(1), 99–126.
Raharjo, H. 2022. Suplemen dan obat herbal: Sejarah serta gambaran pemanfaatannya dalam tindakan preventif dan kuratif pada pandemi covid-19 di Indonesia. Media Bina Ilmiah. 17(12), 7897–7916.
Rahman, H.F., Widoyo, S., Siswanto, H., Biantoro. 2016. Faktor-faktor yang berhubungan dengan kejadian diare di Desa Solor Kecamatan Cermee Bondowoso. NurseLine Journal. 1(1), 24–35.
Rohmah, J., Rini, C.S., Asri, N.I.N., Krisdianti, R. 2022. Antibacterial activity of rhizome extracts of Zingiber zerumbet roscoeex sm. Against Streptococcus pneumoniae. Procedia of Social Sciences and Humanities. 1, 1007–1016.
Rizal, M., Yusransyah, Y., Stiani, S.N. 2017. Uji aktivitas antidiare ekstrak etanol 70% kulit buah jengkol (Archidendron paucifloum (benth.) I.C.Nielsen) terhadap mencit jantan yang diinduksi oleum ricini. Jurnal Ilmiah Manuntung. 2(2), 131.
Soetan, K.O., Oyekunle, M.A., Aiyelaagbe, O.O., Fafunso, M.A. 2006. Evaluation of the antimicrobial activity of saponins extract of sorghum bicolor L. Moench. African Journal of Biotechnology. 5(23), 2405–2407.
Sukmawati, I.K., Sukandar, E.Y., Kurniati, N.F. 2017. Aktivitas antidiare ekstrak etanol daun suji (Dracaena angustifolia Roxb). Pharmacy: Jurnal Farmasi Indonesia. 14(2), 173−187.
Suproborini, A., Laksana, M.S.D., Kartini, P.R., Putri, D.L.P. 2022. Efek antidiare ekstrak etanol daun keji beling (Strobilanthes crispus) terhadap mencit (Mus musculus) Jantan yang diinduksi castor oil. EnviroScienteae. 18(1), 210–215.
Syafitri, N.E., Bintang, M., Falah, S. 2014. Kandungan fitokimia, total fenol, dan total flavonoid ekstrak buah haendong (Melastoma affine D. Don). Current Biochemistry.1(3), 105–115.
To’bungan, N. 2020. Pemanfaatan dan skrining fitokimia infusa daun rumput knop (Hyptis capitata Jacq.). Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati. 5 (3), 149–15.
Yob, N.J., Joffry, S.M., Affandi, M.M.R., The, L.K., Salleh, M.Z., Zakaria, Z.A. 2011. Zingiber zerumbet smith: A review of its ethnomedicinal, chemical, and pharmacological uses. Evid Based Complement Alternat Med.
Yulianti, W., Ayuningtyas, G., Martini, R., Resmeiliana, I. 2020. Pengaruh metode ekstraksi dan polaritas pelarut terhadap kadar fenolik total daun kersen (Muntingia calabura L). Jurnal Sains Terapan. 10(2), 41–49.